Kcentra is a blood coagulation factor replacement product indicated for the urgent reversal of. Click the image and it will be inserted into the slide. Because beriplex is marketed under the name kcentra in the united. The optimal dose of 4fpcc is currently unknown despite multiple studies evaluating different dosing regimens. From insert menu, choose object and then from file once i selected that pdf and any other pdf later i got the following alert message. In the insert object box, select create from file, and then enter the pdf file location. Please see full prescribing information for kcentra, including boxed warning, on page 42. Insert pdf file content into a powerpoint presentation powerpoint. It is ideal for presenting data contained within other. Kcentra prothrombin complex is a blood coagulation factor replacement product. You cant insert or edit pdf content when youre editing a presentation in powerpoint online or for the web. Powerpoint does not insert pdfs as images so the following is the easiest method that allows you to. The proposed package insert document is usually created in microsoft word and submitted as part of the final labeling folder.
Cannot redose kcentra direct oral anticoagulants doac rivaroxaban xarelto, apixaban eliquis, or edoxaban savaysa last dose taken within 35 halflives of doac yes or unknown kcentra 50 unitskg iv x 1 max dose. Turn the package over and insert the plastic spike through diluent stopper. In this case, youll insert the entire pdf into the presentation as an object on a powerpoint slide, which you can open and view during presentation by selecting the pdf object on the slide. Kcentra, prothrombin complex concentrate human, is a blood coagulation factor replacement product indicated for the urgent reversal of acquired. Youll find that only two guides, one horizontal and. Please see accompanying full prescribing information, including boxed warning. Kcentra administration reminders kcentra preparation and. Package insert reference guide for pharmacy students. Kcentra is contraindicated in patients with known anaphylactic or severe systemic reactions to kcentra or any of its components including heparin, factors ii, vii, ix, x, proteins c and s, antithrombin iii and human albumin. Launch powerpoint 2016, and make sure that the guides are visible.
Fresh frozen plasma administration do no mix kcentra with other medicinal products. Mean in vivo recovery of factors ii, vii, ix, x, and proteins c and s following a single iv infusion of kcentra in patients with acute major. How to import pdfs into powerpoint linkedin slideshare. Kcentra preparation and reconstitution instructions. The pdf file should be the first option within the insert dialog window. Send text medication prices vary by pharmacy location or chain and are subject to change. An industrysponsored, prospective, randomized, openlabel, active controlled, multicenter phase iiib, noninferiority study comparing kcentra n 88 and ffp n 88 has completed in november 2012. Kcentra beriplex in europe fii 380800 u fvii 200500 u fix 400620 u fx 5001020 u protein c 420820 u protein s 240680 u small amount of heparin, human albumin, antithrombin iii kcentra prothrombin complex concentrate prescribing information. Emergent reversal of anticoagulation in the ed and icu. Search for and locate the pdf file you want to insert. Kcentra is for use in adults and dosing is based on body weight. How to insert an image from pdf into powerpoint without losing resolution i have been trying to take an image from part of a pdf document and insert it into powerpoint 2011 for mac.
In the insert object dialog box, click create from file. Kcentra is used to quickly reverse the effects of a bloodthinning medicine such as warfarin during a major. How to insert a pdf into powerpoint online tech tips. In normal view, on the slide with the pdf file, click the pdf files icon or image, and then on the insert tab, in the links group, click action. Prospective evaluation of a fixeddose 4factor prothrombin. Evaluation of fixed dose 4factor prothrombin complex. In healthy individuals, administration of a single iv infusion. Please see accompanying full prescribing information, including. In the action settings box, select the mouse click tab if you want to open the pdf with a click, or the mouse over tab if you want it to open when you move the pointer over the pdf file icon.
Download the complete prescribing information for kcentra. Discard partially used vials multiple vials are usually required. Then adjust the powerpoint application window size so you can drag the file in. The fdaapproved dosing is 25 to 50 iu factor ix per kilogram of body weight, depending on. Additionally you can also use the guide options in powerpoint 2016 to add new guides. Practically it is easy to get the image into powerpoint and display it but it always loses quality and is never of a standard that i would use to present to large. The mechanism of action of pccs is important for understanding their therapeutic applications.
An industrysponsored, prospective, randomized, openlabel, active controlled, multicenter phase iiib, non. Prescribing information kcentra prothrombin complex. Emergent reversal of anticoagulation in the ed and icu settings. Apr 22, 2020 kcentra prothrombin complex is a blood coagulation factor replacement product. If you received a lengthy deck that is a pdf, you basically received pictures of each slide. Once you have made guides visible on your powerpoint slides, they show up in the same position on all other slides within the presentation. American college of chest physicians evidencebased clinical practice guidelines. The quality of the pdf file is reduced with this method, but you can open the full pdf file by doubleclicking the image when viewing or editing in normal view.
How much factor is in a vial of pcc versus a unit of ffp. May 21, 2009 how to import pdf s into powerpoint 1. Urgent warfarin reversal kcentra has over 20 years of clinical experience as beriplex outside the us. Kcentra is not approved for reversal of dabigatranrelated bleeding. Annexa4 interim data set, prior to day 30 from the prescribing information. The package insert is also submitted in pdf and spl format. Inserting a pdf as an image is a quick way to present flat data in a noninteractive fashion. Multiple vials of reconstituted kcentra may be pooled in. Download the inkscape application its free and is available for various platforms go here and convert your. Kcentra quick guide app kcentra prothrombin complex. Mean in vivo recovery of factors ii, vii, ix, x, and proteins c and s following a single iv infusion of kcentra in patients with acute major bleeding was 2, 2.
Andexxa coagulation factor xa recombinant, inactivatedzhzo is a recombinant modified human factor xa fxa protein indicated for patients treated with rivaroxaban or apixaban, when reversal of anticoagulation is needed due to lifethreatening or uncontrolled bleeding. Do not send powerpoint files to a commercial printer, they will not print. Find patient medical information for kcentra intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Regional clinical practice guidelines for the rapid. Superior inr reduction at 30 minutes after end of infusion vs plasma. One vial of pcc also contains factors ii, vii, ix, x, proteins c and s, antithrombin iii and a small amount.
Open the emf file in powerpoint and ungroup twice to edit it. Beriplex the package insert uses the trade names beriplex and kcentra interchangeably. Is there a scientific rationale for the use of pcc as a reversal agent for xa. Kcentra is also contraindicated in patients with disseminated intravascular coagulation.
In the following window, make sure standard and not minimum size is chosen. Left click on it and drag the pdf file onto the slide to insert it into powerpoint. Finally, find your converted pdf files and try to insert pdf into powerpoint on mac. Grip the package at its edge and pull the package off the device. Kcentra preparation and reconstitution instructions kcentra.
Insert pdf file content into a powerpoint presentation. Click convert button on the bottom toolbar and wait for converting process finish. Regional clinical practice guidelines for the rapid treatment. The most common indication for treatment was intracranial hemorrhage 28, 71. Emerging anticoagulation reversal issues in emergency. Singledose kcentra 4fpcc the only fdaapproved alternative to plasma for urgent warfarin reversal. Powerpoint does not insert pdfs as images so the following is the easiest method that allows you to place pdf imagespages onto your slides note. Working with powerpoint in office 365 business on a macbook pro running with macos sierra 10. Fixed versus variable dosing of 4factor prothrombin. It contains the vitamin k dependent coagulation factors ii, vii, ix and x, and the antithrombotic proteins c and s.
Take this kcentra coupon to your nearest rite aid pharmacy to receive your discounted price. This document is provided in portable document format pdf. Although prior fda labeling submission requirements have been in the ms word and pdf formats, the fda now requires the package insert portion of. Dec 08, 2015 you typically add more guides in powerpoint using the dragtospawn process that we explain on this page. Insert pdf content into your presentation either as a picture that shows on your slide, or as a document that you can open during your slide show. Four factor pcc kcentra is dosed on the amount of factor ix.
Kcentra is a purified, heattreated, nanofiltered and lyophilized nonactivated fourfactor prothrombin complex concentrate human prepared from human u. Novoseven rt coagulation factor viia, recombinant for hcp. Recently, our hospital instituted a protocol where all doses of 4fpcc were a fixed dose of 1500 iu. Microsoft powerpoint emerging anticoagulation reversal issues in emergency medicine g. Fourfactor prothrombin complex concentrates 4fpccs are emerging as the standard of care for emergent warfarin reversal due to their ability to rapidly and effectively achieve hemostasis. Hit start conversion and then click download once its ready. If cooled, the solution should be warmed to 2025c prior to administration. Kcentra is used to quickly reverse the effects of a bloodthinning medicine such as warfarin during a major bleeding episode, or when there is a need for emergency surgery or invasive medical procedure.
This indication is approved under accelerated approval based on the. Finally, find your converted pdf files and try to insert pdf into powerpoint. Emerging anticoagulation reversal issues in emergency medicine gabby anderson, pharmd. Novoseven rt coagulation factor viia, recombinant is a drug focused on effective bleed control treatment for your patients with hemophilia a or b with inhibitors, congenital factor vii deficiency, glanzmanns thrombasthenia with refractoriness to platelets, and acquired hemophilia. May 3, 2018 summary basis for regulatory action andexxa. Open the package of baxject device by peeling away the lid without touching the inside. Home kcentra prothrombin complex concentrate human.
Reversal of oral factor xa inhibitors by prothrombin complex. Units of factors are ratiobased as compared to factor ix, e. Use a separate, unused mix2vial transfer set for each product vial kcentra is manufactured by csl behring gmbh and distributed by csl behring llc. Regional clinical practice guidelines for the rapid treatment of age 65 head injury patients age 65 head injury patient with any of the following. Instructional guide an instructional guide reconstitution of kcentra ial ransfer set please see full important safety information inside. Andexxa coagulation factor xa recombinant, inactivatedzhzo is a recombinant modified human factor xa fxa protein indicated for patients treated with rivaroxaban or apixaban, when reversal of. One vial of pcc also contains factors ii, vii, ix, x, proteins c and s, antithrombin iii and a small amount of heparin. Kcentra will be stored at room temperature in the pharmacy department at all times.
Powerpoint embeds the pdf and displays an adobe acrobat icon. Pcc may partially correct ptaptt but will not affect antifactor xa activity and will not increase drug clearance. Antithrombotic therapy and prevention of thrombosis, 9thed. How to insert an image from pdf into powerpoint without.
Andexxa coagulation factor xa recombinant, inactivated. Prothrombin complex concentrates in trauma and perioperative. Recheck inr 30 minutes after kcentra dose kcentra4factor pcc dose based on actual body weight up to 100kg. Kcentra is for single use only and must be used within 4 hours following reconstitution. I was asked to insert a pdf in the ppt presentation file and so i followed these steps. Microsoft powerpoint tutorial to setup files for print. Heparin reversal protamine sulfate adjust for time elapsed since last dose. Acrobat can detect the orientation of the majority of the text in your presentation and rotate the resulting pdfs so that the text is horizontal. Dosing of kcentra based upon specific anticoagulantrelated bleeding note. Turn the package over and insert the plastic spike through diluent. Kcentra must be used within 4 hours following reconstitution.
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